GLP-3RT / Retatrutide
RETA is a synthetic peptide that acts as a triple agonist, targeting the Glucagon-like peptide-1 (GLP-1), Glucose-dependent Retatrutide insulinotropic polypeptide (GIP), and Glucagon (GCG) receptors. In laboratory research, it is utilized to study the potentiation of metabolic signaling and the regulation of nutrient-stimulated hormone secretion. Studies focus on its efficacy in modulating glucose homeostasis and observing the synergistic effects of triple-receptor activation on lipid metabolism in experimental models.
“GLP-3” or “GLP-3RT” is an unofficial, social media term for Retatrutide, an investigational triple-hormone-receptor agonist. It is not a real scientific class of hormone, but rather a nickname for drugs targeting three specific receptors: GLP-1, GIP, and glucagon. [1, 2, 3, 4]
- GLP-1 receptor: Controls appetite and slows stomach emptying.
- GIP receptor: Helps manage insulin release and fat handling.
- Clinical Trials: Developed by Eli Lilly, it is currently undergoing late-stage Phase 3 clinical trials for chronic weight management and obesity.














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